Biotechnology Learning Center
 The Biotechnology Learning Center at the Main Library provides access to print and online biotechnology resources.
 
The California Collection
This reference collection includes works of fiction and non-fiction about the history of California and its localities, with an emphasis on San Mateo County.

Franklin Templeton Investments Business Resource Center
The San Mateo Public Library has the largest public library collection of business materials on the Peninsula.

Funding Information Network
Candid's Funding Information Network provides local nonprofits with tools they can use to become successful grant seekers.

The Leon S. Benson Holocaust Studies Collection
This collection is dedicated as a living memorial for Leon S. Benson and all the survivors and victims of the atrocities of the Holocaust.

San Mateo County Genealogical Society Collection
The San Mateo County Genealogical Society supports the study of family history on the San Francisco peninsula and beyond through its collections, educational programs, and research services.